Fracking w Hyaluronic Acid

HOW I IRRIGATE - 02-28-14 - Right now I am largely using hyaluronic acid in thick globs. I am applying it with a brush pick. Plus also use the 16 guage needle combined with the 3cc syringe. I am also experimenting with adding a touch of EDTA as a general surfactant. Plus both Polysorbate 80 (Tween 80) and Propylene Glycol, which function both as surfactants and encapsulators and which can also function as drug-carriers (drug-mules).

In addition hyaluronic acid can also function as a drug mule. But it has long chains, which is a negative when dealing with slipping through narrow spaces and channels in nano-space. But largely use the hyaluronic acid as a thickener and as general promoter of the ECM (extra-cellular matrix. Plus it is a water lover. So it can expand infection and left liberate it out. Plus it is the only thickener I have ever been happy with. But perhaps Xanax gum could be okay.

Doing a bit of work with the urea-papain. But largely just use the fluid without any thickener.

= = =

3MIX-LSTR - plus new creation 4MIX

= = =

POVIDONE IODINE - Has a good reputation. Idea is to mix the iodine in with some water and irrigate very slowly to give the iodine a chance to get exposed to the infection for at least a few minutes. So can use the needle or can also use the irrigator too.

For the needle my guess is a 100% mixture is probably too strong. I have had facial nerves go numb and teeth go numb too. But fortunately I stopped in time and no apparent permanent damage was caused. So figure 100% is DANGEROUS.

Likewise you might want to taper off to say 10%. But I think the mixture might be getting too weak at this point. So how about if we check with the NIH? Yeah. Good idea.

NOTE - KEEP YOUR DILUTIONS STRAIGHT! - The normal concentration of povidone iodine is 10%. So a 10-1 dilution would yield a 1% solution. But for discussion purposes will just talk dilution first and actual concentration second

google - povidone iodine periodontal

SO... turns out the NIH chats about a full mix without dilution. So they don't go crazy about it. So it can't be that dangerous. But I already mentioned the nerve issues. If the infection is deep enough you are going to end up in nerve territory, so I would stay away from 100%

Likewise dentists talk about 50-50 mixes for their patients without supervision. So this seems reasonable too. Or 25% is probably okay too.

GENERAL RULE - The higher the concentration the less you should use it. The lower the concentration the more often you can use it. I haven't really checked the iodine expulsion rate but obviously every day is bad, possibly very bad. Every three days sounds reasonable with low doses. One week on and one week off just in case. Or once a week with a week off every month is probably okay too.

But studies have shown that 100% of the people who use it on a daily or too often basis get thyroid problems. A little bit of iodine is okay. But a lot is toxic. And you can be sure that some of the iodine is getting absorbed.

= = =

BLEACH - USE IN ORAL IRRIGATOR - You can check the ratios yourself. But the general guidelines are to add roughly two teaspoons or a partial tablespoon of bleach to 20 ounces of water to yield roughly a 60-1 dilution. An ounce contains 2 tablespoons or 6 teaspoons. So a perfectly full tablespoon would be 40-1 which is just a bit too strong.

Bleach is actually highly recommended on a fairly common basis. But I wouldn't use it as a mouthwash. That sounds really stupid. I would treat it as a toxic fluid. Which means to make sure it drips out of your mouth and don't swallow for at least a half-hour. Meanwhile work up a good load of spit and keep spitting for the entire half-hour so the direction of all fluids in your mouth is out, not in.

Likewise, since bleach is poisonous, wouldn't do it every day either. Think once a week would be the safest route, skipping weeks, or "getting lazy" as I call it. But realistically could probably also do it every three days without ill effects. Because this gives the body 72 hours to expel the poison before getting subjected again.

= = =

FLUFFING & FRACKING WITH HYALURONIC ACID - HA - Hyaluron - Plus use as debridement agent. Plus use as an infiltrator of biofilm and neo-slayer. Plus potential matrix maker. And good guy mimicry of bad buy biofilm, hence occuping niche. Also to provide soothing and healing environment - start 05-05-12 - DRAFT

UPDATE - 11-01-12 - HA is good as drilling mud. Can adjust density with honey and use a 20 guage needle to drive it into the pocket. It is also good to help the ECM. However, while it does seem to help frack off the calculus it is not a silver bullet. WHY? There is no particular reason for harder calculus to absorb the HA. Possibly if it was used religiously the results might be better. But as a one-time or occasional shot it will not replace mechanical debridement.

UPDATE - 10-24-13 - "I'M A BELIEVER" - again with the HA - really thick thick - lay it into the hole with the brush-pick. Hang out for awhile, so the fluids inside the hole get a chance to mix with the HA. Tried it on my tooth 3-7 abscess and got lots and lots of crud to come out. Maybe not so much relative to a full debridement, but highly significant. Current situation is I debrided the hell out of it over the course of the past year and have various latent areas. Not so say it wouldn't have worked with the thicker calculus, but mostly I concentrated on that with the curette.

ANYWAY... The logic is Polysacharide HA flushes away Polysacharide Biofilm. Is this logic perfect. Yes, this is naturally perfect logic. The HA will naturally penetrate the biofilm and will naturally then lock the biofilm within the HA. Second, calculus is only around 15% water. But even this can be fluffed up some, so some calculus should naturally frack off too.

MEANWHILE... the calculus naturally produces a layer of biofilm slime out of it's hard surface. So the HA can penetrate the slime since it is a polysacharide and so is biofilm. Then this upper layer gets washed away, exposing the harder underlying calculus. The calculus will then produce another layer of biofilm slime over the course of a few days or weeks. So this can get penetrated and washed away too. So over the course of time the HA should be able to wash away quite reasonable calculus constructions. But would not push the luck. Just figure you can make good progress on fairly thin layers. Plus make them softer too and set them up for more mechanical and brutal debridement.

LIKEWISE... Even if the HA is not the great debridement tool imagined or wished for it still does wash away the biofilm and reduce the total bacterial load. So this means the area gets a better chance to heal in the meantime. So again nothing wrong with any of this. From fantastic expectations met to only so-so progress it is still good. Even if it only does it's best for the fine finishing off type debridement and not so well for the gross debridement.

= = =

NEW IDEA - PAPAIN & UREA DEBRIDEMENT - TRADITIONAL MODE OF DEBRIDEMENT FOR OVER 100 YEARS - UNTIL THE FDA BANNED IT - Bottom line is that commercial products consist of roughly 10% urea and 10% papain in some type of base. I am planning on using two bases. One is the HA solution. Which can be a mainstay. Can think of it as enhanced HA. But... this will not last long. It will get washed out. SO... one solution is to simply up the percentage of papain-urea over time, while I see what I can tolerate. Since it washes out so easily if I screw up the consequences should not last too long. Since both substances are inherently tolerable. In this scenario could ultimately go high on both for short periods.

Second scenario is to use a commercial hydrophillic filler as the base. I have this stuff called - Duo-Derm Hydroactive Gel - which is designed to help treat chronic wounds. And which should last longer than the HA. Once I confirm how much urea-papain I can tolerate then will either substitute or add in the commercial filler.

OBJECT - SOFTEN THE DEEP CALCULUS TO PREP IT FOR MECHANICAL DEBRIDEMENT - I figure to work in weekly cycles. That way I will get enough recovery time from the mechanics. Then can ultimately push for microscopic cleanliness. As analogy I think of a cathedral. Consisting of the destroyed bone and tooth walls on the outside. The good. Plus broken walls of calculus on the inside. If the inside calculus walls can be partially disintegrated then they will lose their grip on the outer walls and will become more susceptible to the curette. And should break off and peel off more readily. This will expose inner layers to repeat process. Figure that a religious program of 2x day irrigation with the papain-urea should deliver weakness in roughly a week. Then go through four cycles for a total of 28 days to achieve significant cleanliness.

Also... the papain can disrupt the ECM healing process. So the papain-urea is not without drawbacks. But first the crud has to go and it is like a rock. Virtually impossible to get it to come loose. Thereby dooming the tooth. In addition there are deeper layers so deep right next to both the tooth nerves and other important jawbone nerves too. So a long term plan to free these areas is important too. Or the affected teeth are goners.
= = = = =

CAN HA BE USED TO GET TO THE BOTTOM? Think so, yes. I am trying it right now. Clean it up as well as I can. Then use the brush-picks to remove as much as the plaque as possible. Then attempt to insert the HA with the brush picks to temporarily take over the niche occupied by the plaque. Meanwhile hoping the HA will fluff and frack the leftover calculus. Leading to removal of crud that is very difficult or impossible to remove. Leading hopefully eventually to a clean bottom.

IS THIS REALISTIC? YES - WHY? - For two reasons. First is because it is the ONLY GAME IN TOWN - THERE IS NO CREDIBLE PLAN B - (except for edta) - HA IS IT - HA IS THE ONE - I WORSHIP HA - I LIVE FOR HA - PLEASE PLEASE DO YOU REALLY MEAN THIS? - YES - WHY? - Let's get real. If the hole gets really really deep what other strategies do you have? Besides removing what you can and then waiting for the leftover crud to lift up its head and revitalize itself and stand on its hind feet so you can properly whack it. OR for it to be broken down enough for the body to liquidate it. At which time you can capture it as crud with the brush-pick... BUT! You don't have another 100% hygiene strategy do you? You don't have any other chemical means to lift up the leftover crud out of its spiderholes, nooks and crannies do you? NO HA IS IT.

DANGER ISSUES - MAXILLARY TOP TEETH VS MANDIBLE BOTTOM TEETH - PER POSSIBLE PROBLEM OF HA EXPANDING STRUCTURAL CALCULUS ENOUGH TO CAUSE INJURY-DAMAGE OR EXPAND INNER REGIONS SUCH AS TUNNELS AND FURCATIONS AND NERVE APEXES ETC - There are two primary issues with the uppers. Main issue is the roof of the mouth is biologically constructed as a dome. Indeed you can imagine it almost like a section of an umbrella, with bony ribbed structures providing structural integrity and filler material in between. With leftover developmental channels or natural tunnels that never quite filled in perfectly. Hence if the infection manages to infiltrate beyond the gumline structure into the roof of the mouth the infection can make tunnels. This is very bad. But if you irrigate it with HA before you have otherwise cleared it then it can swell up. I know. It happened to me. And it did clear the infection. But it was puffy and scary for a good four or five days. Before it burst and released its inner crud and detritus. And has been fine for the past year with no problems.
= = =

IS FRACKING THE NEXT GENERATION? WITH FORGET-ABOUT-IT TO GET THE AREA CLEAN AND LARGELY CALCULUS FREE? JUST FRACK! THEN CURETTE! - IS THIS DANGEROUS? ABSOLUTELY YES. IT IS DANGEROUS - So how does this argument work? How would a situation work? First imagine somebody did in fact get a good SRP with no bull. Then this person might just stick in the brush-pick with the glob of HA on the rake-side. Then shake it all around and see what happens. Like a Frankenstein. Then, certainly the area might just swell up dramatically and dangerously. But then again maybe it won't. Additionally what might then present itself would be a lot of crud that could be exited via either fiddling into the area with a toothpick or with the proxy-brushes or brush-picks etc. And it would also presumably set up the curette. So maybe just maybe the large ledges of calculus will cry out "No more! No more!" and just give themselves up to live their new lives in the sewers.

= = =
PURCHASE - HYALURONIC ACID POWDER - NO FILLER! PURE ONLY! - BUY - I got mine from www.herbstoreusa.com - www.herbstoreusa.com/hyaluronic-acid-25g.html - 25 grams of 100% pure food-grade HA for $41 plus shipping. Alternately can buy 100% pure hyaluronic acid in a water base at a major drugstore. It is marketed as eyelid spiderweb fluffer. Idea being to fluff up the wrinkles to minimize them for important social occasions. Or even for regular use. Since it does work and is harmless and can even contribute to making the wrinkles less wrinkly. It works! It does exactly as the cosmetic companies claim! Surprise surprise. But the liquid is expensive. $10 for an ounce of solution. Much cheaper to buy in bulk and make your own solution

OTHER GOOD PURCHASE - LACTOFERRIN - USED TO DISPERSE BIOFILM INTO NON-CONTINUOUS BLOBS - MAKING THEM VULNERABLE - AND TO STIMULATE BONE AND OTHER REGENERATION - I got mine from New Century. But have not really used it much yet (06-24-12) - since didn't have any good ideas for application. But now figured to make a blob of HA on a brush-pick and then roll the blob in Lactoferrin powder. Will try soon. Bullish, per chronic wound theory. OTHER GOOD STUFF IS XYLITOL - ALSO PER CHRONIC WOUND THEORY PLUS STANDARD PERIO THEORY TOO.

NOTE - Use Lactoferrin separately from HA. Don't think lactoferrin dissolves very well. Will try this out... What I am thinking is to make a small pile of lactoferrin, hardly anything at all, and to roll a blob of thick HA on a brush pick into the powder. And then apply. This way the lactoferrin never really has to mix in with the HA while the HA still provides a delivery mechanism. OPINION - Think a strong showing with lactoferrin in a deep cratered pit might stimulate bone. I will try it out on my cratered pit.

OTHER GOOD PURCHASE - EDTA DENTAL CLEANER 17% - CAN BUY FROM DENTAL SUPPLY HOUSE - LEGALLY - ($20 for 3 ounce 100 ml bottle) - IT IS USED AS A STRONG DENTAL CLEANER - AND CAN STRIP TEETH OF SLIME LAYER AND MINERALS TOO. I have not tried this yet to go after the slime layer. But am planning to do so soon. To essentially swap one slime layer (biofilm infected) for a fresh one starting with a nice clean layer of HA followed up with commercial preparation of calcium-tri-phosphate (sensitive teeth reliever & remineralizer) - but this is a big deal and only really worth it if everything is perfectly perfectly clean. Since otherwise you are inviting the bacteria to visit your slime-layer shorn tooth, not a good idea. But otherwise a dash of EDTA added to irrigation water down to say 1% or so helps cut the water to make it flow better and helps the crud escape better. It's basically floor cleaner that is also appropriate for baby food because it is so harmless. It can be considered an ubiquitous substance. It is literally everywhere and in everything and everybody and is generally considered harmless in low concentrations, while having de-mineralizing detergent properties in high concentrations.

EDTA - WHEN YOU ARE READY TO FLY WITH THE BIG BOYS - SLIME LAYER REGENERATION SCENARIOS - DANGEROUS - DON'T DO THIS - DANGEROUS - Meaning to pursue regeneration then EDTA becomes critical. WHAT IS THE THEORY? The theory of regeneration is that normal regeneration is blocked by the epitheleal layer. And that it is the contact between the tooth itself, without much of any slime layer, and the gum itself, without the epithelial membrane is the triggering event of regeneration. BUT... the bone also has the ability to fill-in. But not grow upwards. You can imagine a dirt-mine with various bulldozers. Meaning that theoretically part of the bottom could fill in from each side. Then the two sides could form a middle and maybe even make a substantial recover. General theory is that without special help the maximum here is around 4 mm. Which is slightly over 1/8th inch. And even this claim is dreamy. But can certainly expect 1 mm just for close to perfect hygiene with some recovery. So all in all virtually any yield at all will help keep the tooth in the mouth. SO - If you want to play with regeneration concepts but don't actually want put put yourself in danger then can certainly use 1% or even 2% without much risk. And can even replace the slime layer with "friendlies" ie Novamin. But all of this is a lot of trouble and though I have certainly thought about much of it I am only now ready to start regeneration scenarios.

= = =
GENERAL PROCEDURE -

HYALURONIC ACID GEL - HA MIXED WITH CONTACT LENS SALINE SOLUTION - OR PLAIN WATER - MIX IN SMALL QUANTITIES - TIP OF A COFFEE STIRRER AND LET IT DISSOLVE ON ITS OWN OVERNIGHT IN A SHOT GLASS. PLACE SHOT GLASS INSIDE PLASTIC FOOD CONTAINER WITH ROTATING LID. MIXTURE WILL NOT DEGRADE WITHIN A FEW DAYS IF AT ALL.

LOGIC OF THE HA GEL - I like to view it as a good-guy biofilm that has the ability to crowd out the bad-guy biofilm infection. Is this true? Reasonably. HA forms itself into chains that can be viewed as nano-fibers. Which is not too far off from biofilm, except for not being living. So logically the infection will win in the long term. If it still exists. But in the meantime it is easy enough to imagine the HA infiltrating the infection because of it's love for water. Imbibing gum-plasma and spit too. But also infiltrating the infection and possibly the calculus too. Doing its fluffing thing. Making the infection more subject to the curette, needle or brush pick. Then once the infection is removed then the HA will rule as the standing biofilm. And help to build the matrix for regeneration.

NOTE - Offhand recall the protocol from one study to be to apply the HA twice a day to a clean area for eight weeks. If you get the routing right don't really see a problem with that. Gearing up for that right now for my fairly clean cratered pit on teeth 19-20. Lower left bicuspid & first molar.

WHAT IS THE LOGIC OF THE GEL - MADE BY ADDING WATER TO HA - TO GET IDEAL CONSISTENCY - Logic is that the gel will more or less sustain itself and slowly dissolve away. So a nice well-placed blob of thick gel may last for several hours. Or likewise mix itself with the crud and fluff it up so that when you go after the crud with the curette it gives up easily. Or is not so hard to whack away at. Meanwhile irrigation fluid only lasts maybe fifteen minutes or so.

1) CLEAN ENVIRONMENTS PREFERRED - The preferred relatively safe environment should be already largely clean. This way you can avoid having the HA expand calculus or interior crud to the point where it has no escape. To visualize can imagine as an abscess, except driven by the pressure of the HA absorbing surrounding water. Especially dangerous if you have any tunnels, which I had. ALTERNATE is that the danger is more limited and that HA can realistically be used to frack calculus. So it becomes highly vulnerable to easy removal. I do not know the real answer.

2) REMOVE AMBIENT PLAQUE MECHANICALLY WITH BRUSH PICK - Use single or double brush-pick to explore all regions of the pocket and to allow the ambient plaque to cling to the brush-pick. Continue process until you don't really get much plaque anymore but mostly get spit. (on mandibles). I will very typically spend up to an hour or more just relieving a pocket by brush-pick of its bloody crud and clear plaque. Try to get as many easy blobs of blood (crud) or pure crud as you can. Essentially what you are doing is wet mopping and lightly raking the bottom. Also... true clear non-bloody or cruddy plaque is very very self-adhesive. The way you can tell is if a large blob of clear liquid on a thin strand can effectively resist gravity and even bounce back. That is 100% plaque. Likewise can figure if it fights gravity and easily loses that at best it might be 50% plaque and 50% normal spit. Also... the plaque will tend to self-collect. BUT imagine you are taking plaque from a shallower area and transporting it to a deeper area. Does that sound smart? I would say no. So not to get too finicky think the procedure should largely be to first clear up the shallow areas. Then to go deep. Seems reasonable. Since do have to go in deep and if you take some plaque with you but still pull it out with the main blob then did you really insert plaque down below? Especially if down below was already dirty anyway.

NOTE - SHORTEN BRUSH PICKS BY CUTTING THEM IN TWO. FULL SIZE BRUSH PICKS ARE TOO ANNOYING FOR HA POCKET WORK. USE SPEAR FOR DEEP TAMPERING W RELEASE OF INTER-GUM CREVICULAR FLUID & INFECTION & BY-PRODUCTS. USE ANTENNA FOR PLAQUE & CRUD BLOB CAPTURE. PLUS RELEASE.

3) INSERT HA BLOB INTO POCKET - Presuming clean environment take two half-size brush-picks and insert into the HA like a bowl of honey. Lift up blob. Alternately only use one brush-pick. Twist to keep blob of HA on the two brush-picks. Aim HA Blob at pocket and don't screw up. Insert brush-picks perfectly into pocket. Tilt your head or even tilt your head upside-down if necessary to let gravity allow as much of the HA as possible to flow into the pocket. This is your WORKING BLOB OF HA.

4) HANG OUT. HAVE FUN. EXPLORE THE POCKET. DO PIROUETTES. DO WHATEVER YOU WOULD LIKE TO DO. TRY TO VISIT ALL PARTS OF THE POCKET. JUST KEEP THE BRUSH-PICKS AND HA IN THE POCKET FOR A GOOD TEN MINUTES OR SO TO GIVE THE HA TIME TO WORK ITS WONDERS. ETC. REASON IS YOU WANT TO GIVE THE HA A CHANCE TO MELT INTO THE SURROUNDING TISSUE. IF YOU PULL OUT TOO SOON YOU WILL ALSO PULL OUT THE BLOB OF HA. Note - This is not a one-time wonder. it's a lifestyle. Object is to create a HA spa for the exposed bone and help it relieve itself of vestiges of infection and make a fresh start.

5) MAKE A FRESH START - This means to get to the bottom, reach a clean bottom, encourage the healing process to take command and look forward to the creation of a clean perimeter, without judgement. Healing is a joy unto itself. It does not have to explain itself if it is true.

NOTE - FINAL COUNTDOWN - Much of the FINAL DEBRIDEMENT PROCESS is largely based on LIQUIFICATION. What this means is the body will LIQUIDATE small amounts of crud. So the objective becomes to remove the DETRITUS. Which can largely be thought of as waste products. But not just from the infection but from the body too fighting the infection. SO KEEP IT CLEAN AND THE BODY WILL DO THE FINAL JOB. BE PATIENT. It may take years to turn it around. BUT - how long are you planning to keep your teeth? And if the dentist has given up what loss is it to you?

EXAMPLE - I have been working on my 19-20 gap for over a year. Since June 2011. With perhaps five main debridements. With months of healing and recovery in between each attack. Which oftentimes bordered on both brutal and bloody. Or was indeed.. And only now am I finally getting to the bottom. With my goal to lift the last, like a wooden boat rotted on the bottom of a lake, And finally get to a clean bottom. For which the HA will also serve hopefully as a scaffolding for regeneration.

WINSTON CHURCHILL - What would he say what to do about periodontal infection against the xenomorph occupiers of our teeth?

-- Battles are won by slaughter and maneuver. The greater the general, the more he contributes in maneuver, the less he demands in slaughter.
-- Continuous effort - not strength or intelligence - is the key to unlocking our potential.
-- Do not let spacious plans for a new world divert your energies from saving what is left of the old.
-- All great things are simple, and many can be expressed in single words: freedom, justice, honor, duty, mercy, hope.
-- Every day you may make progress. Every step may be fruitful. Yet there will stretch out before you an ever-lengthening, ever-ascending, ever-improving path. You know you will never get to the end of the journey. But this, so far from discouraging, only adds to the joy and glory of the climb.
-- Never, never, never believe any war will be smooth and easy, or that anyone who embarks on the strange voyage can measure the tides and hurricanes he will encounter. The statesman who yields to war fever must realize that once the signal is given, he is no longer the master of policy but the slave of unforeseeable and uncontrollable events.
-- One ought never to turn one's back on a threatened danger and try to run away from it. If you do that, you will double the danger. But if you meet it promptly and without flinching, you will reduce the danger by half.
-- Personally I'm always ready to learn, although I do not always like being taught.
-- Success is the ability to go from one failure to another with no loss of enthusiasm.
-- I like pigs. Dogs look up to us. Cats look down on us. Pigs treat us as equals.

= = =

REALLY? WELL THERE IS ALSO THE EDTA 17% DENTAL CLEANER - BUT I AM AFRAID OF EDTA -STRIPPING THE TOOTH AND MAKING IT SENSITIVE - REALLY? OK OK SAY IT - EDTA in the form of Dental Cleaner, undiluted at 17% which sounds dangerous, and dilutable down to other mixtures also looks promising to remove crud. Plus it can also remove the slime layer, which has other benefits. So also figure to use EDTA. But HA helps create the Extra-Cellular-Matrix (ECM) so HA is certainly the most versatile. But could use the EDTA to help get things started and then switch to the HA later.

SUMMARY ON EDTA 17% DENTAL CLEANER - MIX DOWN TO BELOW 4% - 4 TO 1 - TREAT THIS AS REAL STRONG AND MIX DOWN TO 2% - ALSO USE THIS FOR SCRUBBING - THEN QUICKLY RINSE - High concentrations of EDTA will not only strip the tooth of its slime layer, which is mostly okay, but can also strip the tooth of minerals. Which is bad. Dentists don't care since it is a one-time event but obviously repeated application of high concentration EDTA can damage the tooth. So stay away. Except for highly special special occasions. Otherwise can dilute

MIX EDTA W HA? - In general I do not like to mix chemicals together that are both chemical in nature. Since the could react in ways I do not understand. So I would tend to use them separately. Plus so far I haven't really used EDTA except as an add-on. But as soon as I get more Regenerative then EDTA is the stuff to use first, then the HA. Since the slime layer has to be attacked. Even at the risk of de-mineralization. However, both substances are dodgy. So start slow and work your way up.

WHAT IS THE MANOUVRE? - PUT A BIG BLOB OF GEL ON THE BRUSH PICK AND STICK IT IN - CAN ALSO USE TWO BRUSH PICKS TOGETHER OR EVEN THREE - TO HOLD BLOB TOGETHER BETTER

MAXIM - CLEAN OUT THE CRUD FIRST - THEN STICK IN THE HA - THAT IS THE IMAGINARY IDEAL. What will hopefully happen then, presuming you cleared out as much as the plaque as possible is that the HA will imaginatively take over from the plaque for a little while. And actually create its own biofilm too! Like Bizarro World. Where the plaque is evil. And the HA is good.

ANYTHING ELSE HERE? - YES - STICK IT IN AND KEEP IT IN FOR A HALF HOUR OR SO TO LET THE HA INFILTRATE THE CALCULUS AND BIOFILM. OR GO IN WITH FRESH HA. - Yes, that taking some time, like even up to a half-hour or more in some pocket with a blob of HA will give the HA a chance to do its wonders. But if you pull out too soon then the effects won't be as good.

- BUT BUT - HA CAN CAUSE DANGEROUS SWELLING - so it is a bad idea to use it in the presence of any large scale active infection unless you start with a very low concentration. It also seems possible that HA could cause especially dangerous swelling in the sinus area. Issue is HA is water-loving. So an infected area might reasonably swell up in size. And if the infection does not have an escape route or it is hard calculus and the infection is deep then - POTENTIALLY HA CAN CAUSE BIG POTENTIAL DANGEROUS PROBLEMS LEADING TO SERIOUS INJURY INCLUDING EXTREME DAMAGE TO TEETH GUMS AND SINUSES OR EVEN DEATH FROM BACTEREMIA OR OTHER COMPLICATION - SUCH AS CAUSING PEOPLE'S HEADS TO EXPLODE - So certainly want to be very very careful not to use HA improperly. HA is to always be respected and treated as potentially dangerous unless you have strong proof the circumstances are OK.

WHAT IS HYALURONIC ACID? - LOOK IT UP - Hyaluronic Acid is very hydrophilic. That means it loves water. Lives for water. This has both good and bad qualities when attempts are made to use this substance for periodontal hygiene. To use in irrigation fluid.

IS HYALURONIC ACID DANGEROUS? - YES IT IS DANGEROUS -INDEED IT COULD CAUSE A MAJOR INTERNAL EXPANSION - Imagine irrigating an infected area with hyaluronic acid. What will happen, logically? The living tissue should be able to resist any negative effects. Why? Because living tissue can self-regulate itself and hyaluronic acid is not poisonous. In fact it is a major part of living tissue. But what about when the hyaluronic acid mixes with infected material? Logically this will act as a fluffer. Meaning it will cause the infected material to increase in volume.

COUNTERPOINT - DON'T STICK IT IN TOO DEEP. AT LEAST NOT AT FIRST - - LOGIC?? - It is generally accepted that irrigation will not penetrate much deeper than the tip of the brush pick. What this means is that as long as excess pressure is not used on the irrigation needle the HA will NOT tend to go in deep. IS THIS LOGIC SOUND? - Think so. Your call. Anyway can imagine applying the HA Gel at higher layers. Fracking them. Then working your way down.

HOW DO YOU MAKE HYALURONIC ACID GEL? - Recommend getting several shot glasses at Salvation Army. Wash. Only use pure Hyaluronic Acid powder. No pills and buffer. Use a wooden coffee stirer from Starbucks as your spatula. Lift up a medium size height of HA powder and drop it into the shot glass. Take contact lens saline water and drop drops along the edge of the shot glass to corral the HA in the middle. Then add more drops to wet. Then put shot glass inside of food container to shield it from dust and bacteria. Flat pint size containers work well. Then wait for several hours until the available HA has imbibed all available water. This is how you adjust the thickness of the gel. Which then gets blobbed onto brush picks to be inserted into periodontal pocket, which hopefully is not going to explode from the hydrophillic chemical properties of the HA.

NOTE - CURRENTLY EVACUATING POCKET BIOFILM IN LARGE QUANTITIES TO MAKE ROOM FOR HYALURONIC ACID - What this means is that the volume of pre-existing internal biofilm infection combo may be many times more than the HA you can add to the party. So once things get fairly clean good idea to evaculate the biofilm first. That way you can add the HA to a relatively clean field. Which can even conceivably chase out the pre-existing infection in its various forms.

WHAT ABOUT CAUSING ABSCESSES TO EXPLODE INSIDE YOUR HEAD? - Realistically figure that brush picks and gel will largely limit the application to more superficial areas that can reasonably evacuate or fluff themselves up fairly well without causing swelling. So if go from shallow to deep then good chance won't screw up too badly. Or if it does swell hope can always hope and pray that no real bad permanent damage gets caused.

DO YOU KNOW IN FACT THAT HYALURONIC ACID (HA) WILL FLUFF UP INFECTIONS AND FLUFF UP CALCULUS? IN EITHER POSITIVE OR NEGATIVE WAYS? - Think the evidence is solid enough to support this conclusion. For starters based on it's hydrophilic qualities as a fluffer.

ANECDOTE #1 - Roughly a year ago I irrigated HA into a deep tunnel in an attempt to get the infection inside the tunnel to flush itself out. Within a number of hours the roof of my mouth swelled up in a very scary way. For around 5 days or so. All the time I attempted to suck out the infection with the aspiration needle and then finally suceeded. The problems with the tunnel then went away for the time being. But I could have very easily have caused serious injury. If the expansion and swelling was in a less friendly area.

ANECDOTE #2 - This one is less compelling. But recently, after extensive debridement, I irrigated out a deep crater on my lower left first molar-mesial for a period of roughly 10 minutes or so with a strong solution of HA and then when I used the water pick to blast out the area out popped a large gigantic piece of calculus, literally resembling a small raisin, presumably from the bottom of the pit, which I suspect was liberated due to fluffing and fracking from the HA. Is this true? Don't have proof. But think it is true.
.

ANECDOTE #3 - This one is also compelling. New strategy to use globs of HA on the end of a brush pick. Like a ball of honey. Have a deep pocket approaching the nerve on tooth #30 mesial - the front of my lower right second molar - from an abscess that destroyed the survivability of my first molar, tooth #30, from resorption. So this tooth is dicey too. Anyway lowered the blob into the bottom of the fairly clean hole, brushed around the brush pick and dislodged a relatively gigantic piece of crud. Hence demonstrating the fracking principle. Is this what really happened? YES, AT LEAST 75% SURE - With some possibility the piece was getting ready to give itself up anyway. But realistically it was the fracking that dislodged it. And likely from right around the nerve too. Hence demonstrating the viability to actually achieve the magic 100% hygiene. By using fracking to dislodge even the very last vestiges of the infection. Per Debridement Doubling Theory.

BLAST - IT WAS A CORNFLAKE OR LEFTOVER NOT CALCULUS - Good point. Touche. But then why there and then? Because you did not brush pick it properly before! Good point. But still think it was the fracking.

FLUFFER? WHAT IS A FLUFFER? - Idea is that the infection will absorb the HA and increase in volume. Potentially this can cause the calculus to "frack" or literally stress against itself. Or it can cause thin layers of burnished calculus to get fatter too. Making them more prone to get debrided by either the toothpick, curette or needle.

WHAT IS THE DANGER AND DO YOU KNOW ABOUT THIS PERSONALLY? - YES - IF THE HYALURONIC ACID IS IRRIGATED INTO AN INFECTED AREA THE AREA MAY FLUFF UP SO MUCH TO CAUSE THE AREA TO SWELL. UP AND PERHAPS EVEN TO SWELL UP IN A DANGEROUS WAY. ESPECIALLY IF THERE IS NO READY EXIT ROUTE FOR THE CALCULUS AND INFECTION TO ESCAPE. PLUS OBVIOUSLY... HOW ARE THICK LAYERS OF CALCULUS SUPPOSED TO ESCAPE? WON'T THEY JUST EXPAND AND LIKELY CAUSE SERIOUS INJURY? YES. IT COULD CAUSE SERIOUS INJURY. BUT MAYBE NOT TOO. MAYBE THERE IS A WAY AROUND THIS PROBLEM.

WHAT DOES THIS MEAN? - What it basically means is that HA is dangerous to use in a highly contaminated area where the expansion is likely to cause injury. But it is presumably less dangerous in an area that is relatively clean. In other words for detailed cleanup work of fairly debrided areas the HA may have strong applications.

OK OK ENOUGH ENOUGH - WHAT IS THE IDEA? - For highly infected areas could experiment with highly diluted solutions of HA and see if it causes problems. Then if it doesn't then up the mixture. For minimally infected areas can use a stronger solution. And presumably it will fluff up the leftover latent calculus to make it easier to scrape off. Or may even frack the calculus so it becomes more susceptible to the irrigation-aspiration debridement needle.

WHAT ARE YOUR PLANS - HAVE YOU EVER DONE THIS IN A SERIOUS WAY? NO - I have always been too afraid of HA since my scary experience. But have irrigated it into a few fairly open areas without much to say about it either way. Plan is to use it for a crater on tooth 19-20 and see if I can get it to do what I say it can do.

IS THIS ALSO A GOOD WAY TO GET THE DEEPEST LAYERS THAT ARE THE MOST INACCEPTIBLE? YES - In particular is the dilemma about what to do about calculus that has infiltrated the nerve.

WHAT ARE YOUR PLANS RIGHT NOW FOR CALCULUS INVADING THE NERVE? - My current general logic is that if the area all around the calculus can be made to become fairly clean and healed that the calculus right around the nerve will want to expand its terrain, gangland style. Then once it sticks its nose out of its hole if I can get the curette to latch onto it then maybe can extract it from its spiderhole.

YOU MEAN THAT CALCULUS RIGHT AROUND THE NERVE IS SORT OF LIKE A SPIDERHOLE? YES - If you can then latch onto anything sticking out you can pull the entire thing out, hopefully, or maybe a good portion. Likewise it is also possible for the calculus to reanimate itself and fluff up on it's own and lose some of its attachment to the tooth right around the nerve and just pop out. But otherwise it is like a hostage situation.

HOSTAGE SITUATION? HOW IS THAT? - When the calculus invades right around the nerve when you attempt to remove the calculus there is a strong possibility of damaging or even destroying the nerve. Likewise if the calculus is allowed to stay it will also eventually kill the nerve. If there is still any bone support. So calculus around the nerve is end-game for the tooth. So HA is one way to address this dilemma. If done so in a good way and not in a damaging way.

DOES HYALURONIC ACID HAVE OTHER GOOD QUALITIES? YES - One of the most important qualities is that HA helps to form the Extra-Cellular Matrix (ECM) - which is the primary vehicle for wound healing. As such HA is a Substance of Interest to any imaginary exercises in healing and regeneration. Also apparently HA is unfriendly to bacteria. Meaning that bacteria don't like HA. But not to say that the HA kills bacteria directly. Rather it seems like it is more of a propensity for the HA and bacteria not to want to coexist together, due to the unfriendliness.

BUT WON'T THE GUMS JUST WASH AWAY THE HYALURONIC ACID WITHIN MAYBE FIFTEEN MINUTES? YES - Yes, the gums produce a fluid, forgot the name, which is similar to saliva and which is also similar to plasma and inter-cellular fluid. And yes, it will tend to wash away just about anything within around fifteen minutes or so.

WHAT DOES THIS MEAN? What it largely means is that most irrigation fluid are not much more effective than water. That water is indeed the great sanitizer. But without getting all worked up and overzealous and unreasonable that other substances also have their place. But they are more like a short spa than long term therapeutic. Unless you have some brainy ideas about how to keep them inside under the gumline.

WHAT ARE SOME BRIGHT IDEAS TO KEEP SUBSTANCES UNDER THE GUMLINE? One idea would be a long-lasting irrigation. Which is probably what I will do. And do naturally anyway. Since it can be so tough to get the stuff to come out of the needle. Here slowly push out the fluid. Which means the tissue is exposed for at least the duration of the irrigation. Have a few other ideas too. For example using olive oil as the irrigation. Or gelatin. Or gel wound dressing (which also has its dangers, especially with active infection.)

HOW ABOUT OTHER STUFF? - LIKE BIOTENE? - I also like Biotene. Which has lots of good stuff in it. Plus like Lactoferrin, which helps break up biofilm. Plus like Xylitol, which is a sugar the bacteria cannot eat. Can make a pretty good mixture that is not too biting by mixing 50/50 Biotene and water. Then add some extra xylitol etc. Or just use the Biotene. Which is reasonable harmless, but still can sting in deep. So maybe it is not completely harmless.

HAVE YOU DONE THIS OTHER STUFF? SOME BUT MOSTLY NOT A LOT. WILL OFTEN JUST USE WATER. WHY NOT USE THE EXOTICS? Mainly for the reasons described. But also because of simple laziness. Since it is so easy to just use water or do nothing.

= = = = JUNK

RADICAL RADICAL MAD SCIENTIST LIKELY DANGEROUS PRESUMABLY ASSUMABLY INDUBITABLY - WHAT WOULD HAPPEN IF YOU SOAKED YOUR TEETH IN A TRAY IN HYALURONIC ACID (HA) CAN PRESUME HIGHLY DANGEROUS - OR ALTERNATELY IRRIGATED INTERIOR POCKETS THAT HAD NOT BEEN ADEQUATELY CLEANED FIRST - IF INDEED HYALURONIC ACID IS INTENDED FOR THE ORIGINAL ATTACK - TO THEN BE APPROACHED WITH DEBRIDEMENT WITH CURETTES AFTER CALCULUS HAS BEEN FLUFFED UP - OPINION - HIGHLY DANGEROUS SINCE THE HYALURONIC ACID CAN EXPAND THE CALCULUS IN DANGEROUS WAYS. But certainly it would be nice to have some help whacking the calculus by making it more subservient.

ALTERNATE OPINION - STAY AWAY FROM TUNNELS & TAKE YOUR TIME TO WORK YOUR WAY DOWN WITH THE HYALURONIC ACID. WHAT'S THE HURRY? GOT A STAGE TO CATCH? THEN GO FOR THE CURETTES TO ATTACK THE FLUFFED UP CALCULUS. MAY NOT BE SO DANGEROUS AFTER ALL. SO WOULD START REAL SLOW AND HOPE DON'T SCREW UP. ALSO... IF THERE REALLY WAS SOME INTERNAL CHAMBER WOULDN'T OPENING UP AT LEAST PREVENT IT A LITTLE FROM GOING POSTAL? Yeah, as a counter-argument that sounds reasonable. And if you think about it realistically and go conservative you can probably start slowly and build up and largely avoid dangerous use. You can think of it as running stop signs on a bicycle. Most of the time it is cool. But not always. And hope you don't have poor brakes. It's not going to be funny when you are lying on the ground screaming. Plus if your not in a tunnel and you have a profound expansion of things that are breakable and not so monolithic then possibly getting so much crud out at once will prove to be a good thing in the end, after the swelling has gone down and things have had a chance to heal and after hopefully no permanent harm has been done.

= = =

GENERAL ANSWER TO FRANKENSTEIN STUFF - The issue is largely technical. On a theoretical basis the general theory has close to universal acceptance. To get the periodontal membrane to regenerate every last speck of calculus has to be removed from the tooth all the way down to the nerve. Then the tooth has to be "conditioned" which just means specially cleaned with citric acid or TCP so the tubules are exposed. Then Voila! Regeneration.

The problem is that it is close to impossible to get rid of all the calculus. In fact I do not have even one tooth that does not still have a huge problem with latent calculus deep down the roots. In spite of dozens upon dozens of hours.

I have one single-rooted bicuspid tooth #29 where I have spent over 40 hours cleaning the tooth. Could turn out this is the tooth where I may practice any regeneration theory. But what about the rest of them? Forget about it.

SUMMARY ON REGENERATION - It is a waste of time to try to get a dirty tooth to regenerate. If the tooth can regenerate it won't need any special potions to help it. It will regenerate all on its own.

SUMMARY - SPECIAL POTIONS ARE LARGELY A WASTE OF TIME. With exceptions of general flushing and debridement - Hydrocolloids & Hyaluronic Acid. Plus Debridement solutions - Urea-Papain.

BUT WHO KNOWS - Knox gelatin largely seems benign enough. Glue might be benign too. Or you could be feeding the bacteria. So probably not much downside.

ALSO - Liquid calcium - such as Arm & Hammer Whitening Booster - Novamin - etc can have their place - but if the hole is deep enough they could cause nerve damage. But otherwise look useful for resorption issues and also for cavity neutralization efforts.